Actor Robbie Coltrane, who played Hagrid in the Harry Potter films, has died aged 72.
He also appeared in ITV detective drama Cracker and the James Bond films Goldeneye and The World Is Not Enough.
In a statement, his agent Belinda Wright confirmed the actor died in hospital near Falkirk in Scotland.
She described Coltrane as a "unique talent", adding his role as Hagrid "brought joy to children and adults alike all over the world".
"For me personally I shall remember him as an abidingly loyal client. As well as being a wonderful actor, he was forensically intelligent, brilliantly witty and after 40 years of being proud to be called his agent, I shall miss him.
"He is survived by his sister Annie Rae, his children Spencer and Alice and their mother Rhona Gemmell. They would like to thank the medical staff at Forth Valley Royal Hospital in Larbert for their care and diplomacy.
Coltrane was made an OBE in the 2006 New Year's honours list for his services to drama and he was awarded the Bafta Scotland Award for outstanding contribution to film in 2011.
The Scottish star, whose real name is Anthony Robert McMillan, was born in Rutherglen, South Lanarkshire, in 1950.
Coltrane was the son of teacher and pianist Jean Ross and GP Ian Baxter McMillan, and was educated at independent school Glenalmond College in Perth and Kinross.
The actor's career began in 1979 in the TV series Play for Today, but he came to prominence in A Kick Up the Eighties, a BBC TV comedy series which also starred Tracey Ullman, Miriam Margolyes and Rik Mayall.
He also appeared in the 1983 ITV comedy Alfresco, with Fry, Emma Thompson, Siobhan Redmond and Hugh Laurie.
By 1987 he had a leading role in Tutti Frutti, about Scottish rock and roll band The Majestics, which also starred Emma Thompson and Richard Wilson. The year before he was in British crime film Mona Lisa, starring Bob Hoskins.
Coltrane gained further fame starring as criminal psychologist Dr Eddie "Fitz" Fitzgerald in the ITV series Cracker from 1993 to 1995 and in a special return episode in 2006.
The role secured him the Bafta award for best actor for three consecutive years from 1994 to 1996.
Arguably his best-known role came in the Harry Potter film series as he starred in all eight movies as Rubeus Hagrid alongside Daniel Radcliffe, Rupert Grint and Emma Watson.
In 2016, he starred in Bafta-winning Channel 4 drama National Treasure, with Dame Julie Walters, about a comic and TV host accused of sexual abuse of women.
Late last year he appeared in the Harry Potter reunion TV special, which reunited the cast, although JK Rowling was absent and featured only in archive video clips.
Coltrane appeared alongside Radcliffe, Emma Watson and Rupert Grint, along with Helena Bonham Carter, Jason Isaacs, Gary Oldman and Ralph Fiennes.